Particle Size Analysis
Advanced dynamic light scattering (DLS) for the measurement of complex and turbid samples.
Dynamic light scattering (DLS) is a widely used method for determining the size of particles in suspension. It is also known as photon correlation spectroscopy or quasi-elastic light scattering and is one of the most popular techniques for the determination of nanoparticles.
Typical applications include the characterization of emulsions, micelles, polymers, proteins, nanoparticles and other colloidal systems.
DLS particle size analysis
Dynamic Light Scattering (DLS, also known as Photon Correlation Spectroscopy or Quasi-Elastic Light Scattering) is one of the most popular light scattering techniques because it allows particle sizing down to 1 nm diameter. Typical applications include emulsions, micelles, polymers, proteins, nanoparticles or colloids. The principle is simple: The sample is illuminated by a laser beam and the fluctuations of the scattered light at a known scattering angle are detected by a detector. From a microscopic point of view, the particles scatter the light and thereby imprint information about their motion. Analysis of the variation of the scattered light provides information about the particles.
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Extend the measurable range of samples using LS Instruments’ advanced DLS
Founded by leading researchers in colloid physics, LS Instruments has built a reputation for instruments that can measure the most complex samples.
With modulated 3D DLS, LS Instruments has brought to market a unique technology that takes the strengths of classical DLS and adds more. Coupled with high-quality optics and high-power lasers, and a team of scientific experts, we offer solutions for the most advanced particle characterization challenges. This technological leadership makes our instruments indispensable in various sectors, including life sciences, personal care, chemistry, and advanced materials, as well as the food and beverage industry, meeting the needs of research and development.
Application Example: Particle sizing in turbid nano-emulsion vaccine adjuvant

Understanding the impact of lipid nanoparticle size on immunogenicity represents an important step for enabling the rapid development of novel vaccines against known or emergent diseases.
Read in this application how the advanced DLS from LS Instruments enables the reliable measurement of particle size in a nanoemulsion at product concentration and high turbidity.
Featured instrument: NanoLab 3D

The NanoLab 3DTM is a benchtop DLS instrument equipped with the advanced DLS from LS Instruments. It enables the measurement of:
» Particle size & polydispersity
» Viscosity
Highest-quality optics coupled with the unique and patented multiple scattering filter technology enable the measurement of the widest range of samples.
Featured instrument: LS Spectrometer II

The LS SpectrometerTM II is a goniometer-based multi-angle light scattering instrument for comprehensive particle characterization:
» Particle size & polydispersity
» Particle shape
» Molecular weight
» Sample structure & particle interactions
» Viscosity
The instrument offers an unparalleled platform for light scattering experiments and, thanks to its modular design, a very versatile solution that can be optimized to meet specific customer requirements.